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2e5k
From Proteopedia
(Difference between revisions)
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==Solution structure of SH3 domain in Suppressor of T-cell receptor signaling 1== | ==Solution structure of SH3 domain in Suppressor of T-cell receptor signaling 1== | ||
| - | <StructureSection load='2e5k' size='340' side='right'caption='[[2e5k | + | <StructureSection load='2e5k' size='340' side='right'caption='[[2e5k]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2e5k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2e5k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5K FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5k OCA], [https://pdbe.org/2e5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5k RCSB], [https://www.ebi.ac.uk/pdbsum/2e5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5k ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5k TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5k OCA], [https://pdbe.org/2e5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5k RCSB], [https://www.ebi.ac.uk/pdbsum/2e5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5k ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5k TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/UBS3B_HUMAN UBS3B_HUMAN] Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.<ref>PMID:15159412</ref> <ref>PMID:17880946</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Muto | + | [[Category: Muto Y]] |
| - | + | [[Category: Shirouzu M]] | |
| - | [[Category: Shirouzu | + | [[Category: Sukegawa S]] |
| - | [[Category: Sukegawa | + | [[Category: Terada T]] |
| - | [[Category: Terada | + | [[Category: Tsuda K]] |
| - | [[Category: Tsuda | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of SH3 domain in Suppressor of T-cell receptor signaling 1
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Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Muto Y | Shirouzu M | Sukegawa S | Terada T | Tsuda K | Yokoyama S
