This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2en2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:52, 29 May 2024) (edit) (undo)
 
Line 1: Line 1:
==Solution structure of the C2H2 type zinc finger (region 598-626) of human B-cell lymphoma 6 protein==
==Solution structure of the C2H2 type zinc finger (region 598-626) of human B-cell lymphoma 6 protein==
-
<StructureSection load='2en2' size='340' side='right'caption='[[2en2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2en2' size='340' side='right'caption='[[2en2]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2en2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EN2 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2en2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EN2 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2en2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2en2 OCA], [https://pdbe.org/2en2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2en2 RCSB], [https://www.ebi.ac.uk/pdbsum/2en2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2en2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2en2 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2en2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2en2 OCA], [https://pdbe.org/2en2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2en2 RCSB], [https://www.ebi.ac.uk/pdbsum/2en2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2en2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2en2 TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
+
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
+
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 29: Line 29:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Abe, H]]
+
[[Category: Abe H]]
-
[[Category: Kigawa, T]]
+
[[Category: Kigawa T]]
-
[[Category: Kobayashi, N]]
+
[[Category: Kobayashi N]]
-
[[Category: Koshiba, S]]
+
[[Category: Koshiba S]]
-
[[Category: Li, H]]
+
[[Category: Li H]]
-
[[Category: Structural genomic]]
+
[[Category: Saito K]]
-
[[Category: Saito, K]]
+
[[Category: Sato M]]
-
[[Category: Sato, M]]
+
[[Category: Tochio N]]
-
[[Category: Tochio, N]]
+
[[Category: Tomizawa T]]
-
[[Category: Tomizawa, T]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Transcription]]
+
-
[[Category: Zf-c2h2]]
+

Current revision

Solution structure of the C2H2 type zinc finger (region 598-626) of human B-cell lymphoma 6 protein

PDB ID 2en2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2en2"
Personal tools