This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1dp6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1dp6.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1dp6.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1dp6| PDB=1dp6 | SCENE= }}
{{STRUCTURE_1dp6| PDB=1dp6 | SCENE= }}
-
'''OXYGEN-BINDING COMPLEX OF FIXL HEME DOMAIN'''
+
===OXYGEN-BINDING COMPLEX OF FIXL HEME DOMAIN===
-
==Overview==
+
<!--
-
The FixL heme domain serves as the dioxygen switch in the FixL/FixJ two-component system of Rhizobia. Recent structural studies of the Bradyrhizobium japonicum FixL heme domain (BjFixLH) have suggested an allosteric mechanism that is distinct from the classical hemoglobin model. To gain further insight into the FixL sensing mechanism, structures of BjFixLH bound to dioxygen, imidazole, and nitric oxide have been determined. These structures, particularly the structure of BjFixLH bound to its physiological ligand, dioxygen, have helped to address a number of important issues relevant to the BjFixLH sensing mechanism. On the basis of the oxy-BjFixLH structure, a conserved arginine is found to stabilize the dioxygen ligand in a mode reminiscent of the distal histidine in classical myoglobins and hemoglobins. The structure of BjFixLH bound to imidazole elucidates the structural requirements for accommodating sterically bulky ligands. Finally, the structure of BjFixLH bound to nitric oxide provides evidence for a structural intermediate in the heme-driven conformational change.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10747783}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10747783 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10747783}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Pas domain]]
[[Category: Pas domain]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:06:24 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:24:28 2008''

Revision as of 20:24, 30 June 2008

Image:1dp6.png

Template:STRUCTURE 1dp6

OXYGEN-BINDING COMPLEX OF FIXL HEME DOMAIN

Template:ABSTRACT PUBMED 10747783

About this Structure

1DP6 is a Single protein structure of sequence from Bradyrhizobium japonicum. Full crystallographic information is available from OCA.

Reference

New mechanistic insights from structural studies of the oxygen-sensing domain of Bradyrhizobium japonicum FixL., Gong W, Hao B, Chan MK, Biochemistry. 2000 Apr 11;39(14):3955-62. PMID:10747783

Page seeded by OCA on Mon Jun 30 23:24:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dp6"
Personal tools