1dqb

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[[Image:1dqb.gif|left|200px]]
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{{STRUCTURE_1dqb| PDB=1dqb | SCENE= }}
{{STRUCTURE_1dqb| PDB=1dqb | SCENE= }}
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'''NMR STRUCTURE OF THROMBOMODULIN EGF(4-5)'''
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===NMR STRUCTURE OF THROMBOMODULIN EGF(4-5)===
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==Overview==
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A glycosylated fragment of thrombomodulin containing two epidermal growth factor-like domains (TMEGF45) was analyzed by NMR. The 4th-domains structure of this two-domain fragment is similar to that of the individual domain previously determined. The 5th-domain, which has uncrossed disulfide bonds, is not as well determined in the two-domain fragment than the individual domain previously solved. The flexibility of the 5th-domain is consistent with low heteronuclear NOEs. In the individual 5th-domain, Met 388 was disordered, and key thrombin binding residues formed a hydrophobic core. By contrast, in TMEGF45, Met 388 is in the 5th-domain core, positioned by Phe 376 from the 4th-domain. As a result, key thrombin binding residues that were in the core of the individual domain are expelled. Upon thrombin binding, chemical shifts of two residues in the 4th-domain, the three interdomain linker residues, and nearly all of the 5th-domain are perturbed. Thus, TMEGF45 binds thrombin by an induced fit mechanism involving a flexible 5th-domain.
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The line below this paragraph, {{ABSTRACT_PUBMED_10700277}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10700277 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10700277}}
==About this Structure==
==About this Structure==
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1DQB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQB OCA].
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1DQB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQB OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:08:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:27:28 2008''

Revision as of 20:27, 30 June 2008

Image:1dqb.png

Template:STRUCTURE 1dqb

NMR STRUCTURE OF THROMBOMODULIN EGF(4-5)

Template:ABSTRACT PUBMED 10700277

About this Structure

1DQB is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the smallest cofactor-active fragment of thrombomodulin., Wood MJ, Sampoli Benitez BA, Komives EA, Nat Struct Biol. 2000 Mar;7(3):200-4. PMID:10700277

Page seeded by OCA on Mon Jun 30 23:27:28 2008

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