6ntl
From Proteopedia
(Difference between revisions)
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==Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-234== | ==Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-234== | ||
| - | <StructureSection load='6ntl' size='340' side='right'caption='[[6ntl]]' scene=''> | + | <StructureSection load='6ntl' size='340' side='right'caption='[[6ntl]], [[Resolution|resolution]] 2.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NTL FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6ntl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NTL FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ntl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ntl OCA], [https://pdbe.org/6ntl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ntl RCSB], [https://www.ebi.ac.uk/pdbsum/6ntl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ntl ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PE:2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL'>7PE</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=L1M:ethyl+(R)-N-[(1E)-1-(diethylamino)ethylidene]phosphonamidate'>L1M</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ntl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ntl OCA], [https://pdbe.org/6ntl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ntl RCSB], [https://www.ebi.ac.uk/pdbsum/6ntl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ntl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bester SM]] | [[Category: Bester SM]] | ||
Current revision
Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-234
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