6pk2
From Proteopedia
(Difference between revisions)
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==CRYSTAL STRUCTURE OF THE CARBOXYLTRANSFERASE SUBUNIT OF ACC (ACCD6) IN COMPLEX WITH INHIBITOR QUIZALOFOP-P derivative FROM MYCOBACTERIUM TUBERCULOSIS== | ==CRYSTAL STRUCTURE OF THE CARBOXYLTRANSFERASE SUBUNIT OF ACC (ACCD6) IN COMPLEX WITH INHIBITOR QUIZALOFOP-P derivative FROM MYCOBACTERIUM TUBERCULOSIS== | ||
| - | <StructureSection load='6pk2' size='340' side='right'caption='[[6pk2]]' scene=''> | + | <StructureSection load='6pk2' size='340' side='right'caption='[[6pk2]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PK2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6pk2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PK2 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pk2 OCA], [https://pdbe.org/6pk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pk2 RCSB], [https://www.ebi.ac.uk/pdbsum/6pk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pk2 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.402Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ORJ:2-{4-[(6-fluoro-1,3-benzothiazol-2-yl)oxy]-2-hydroxyphenyl}-N-methylacetamide'>ORJ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pk2 OCA], [https://pdbe.org/6pk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pk2 RCSB], [https://www.ebi.ac.uk/pdbsum/6pk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pk2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACCD6_MYCTU ACCD6_MYCTU] Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit transfers the CO2 from carboxybiotin to the CoA ester substrate (PubMed:17114269). When associated with the alpha3 subunit AccA3, is involved in the carboxylation of acetyl-CoA and propionyl-CoA, with a preference for acetyl-CoA (PubMed:17114269).<ref>PMID:17114269</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Michele TCB]] | [[Category: Michele TCB]] | ||
[[Category: Nian Z]] | [[Category: Nian Z]] | ||
[[Category: Reddy MCM]] | [[Category: Reddy MCM]] | ||
[[Category: Sacchettini JC]] | [[Category: Sacchettini JC]] | ||
Current revision
CRYSTAL STRUCTURE OF THE CARBOXYLTRANSFERASE SUBUNIT OF ACC (ACCD6) IN COMPLEX WITH INHIBITOR QUIZALOFOP-P derivative FROM MYCOBACTERIUM TUBERCULOSIS
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