Serum amyloid P-component

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== Function ==
== Function ==
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'''Serum amyloid P-component''' (SAP) is known as a synaptic vesicle-associated protein involved in the regulation of exo- and endocytosis processes at presynaptic sites<ref>PMID:26679993</ref>.
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'''Serum amyloid P-component''' (SAP) is a plasma protein and is the precursor of amyloid P-component which is constituent of deposits in amyloidosis and Alzheimer disease<ref>PMID:8202534</ref>.
== Relevance ==
== Relevance ==
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Rab is a major auto antigen in lymphocytic infundibulo-neurohypophysitis (LINH). Antibodies to Rab may serve as a biomarker for the diagnosis of LINH<ref>PMID:25919460</ref>.
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Mutations in SAP affect the aggregation of mutated lysozyme which cause amyloidosis. The inhibition of SAP binding to amyloid fibrils is a therapeutic target in some serious human diseases<ref>PMID:26176329</ref>.
== Structural highlights ==
== Structural highlights ==

Revision as of 11:24, 18 February 2021

Structure of rabphilin-3A C2B domain (green, grey, pink) complex with SNAP-25 N-terminal helix (yellow, magenta), glycerol, sulfate and Ca+2 ions (PDB code 5lob)

Drag the structure with the mouse to rotate

3D Structures of serum amyloid P-component

Updated on 18-February-2021

1sac – hSAP – human
2a3w, 2a3x, 2a3y – hSAP + bivalent ligand
1gyk – hSAP + galactose derivative
1lgn – hSAP + AMP derivative
2w08 – hSAP + Thr derivative
4avs, 4avt, 4avv, 4ayu – hSAP + Pro derivative
3kqr – hSAP + ethanolamine derivative
3d5o – hSAP + Igg Fc receptor
1qtj – SAP – Limulus polyphemus


References

  1. ↑ Pepys MB, Rademacher TW, Amatayakul-Chantler S, Williams P, Noble GE, Hutchinson WL, Hawkins PN, Nelson SR, Gallimore JR, Herbert J, et al.. Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5602-6. doi: 10.1073/pnas.91.12.5602. PMID:8202534 doi:http://dx.doi.org/10.1073/pnas.91.12.5602
  2. ↑ Richards DB, Cookson LM, Berges AC, Barton SV, Lane T, Ritter JM, Fontana M, Moon JC, Pinzani M, Gillmore JD, Hawkins PN, Pepys MB. Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component. N Engl J Med. 2015 Sep 17;373(12):1106-14. doi: 10.1056/NEJMoa1504942. Epub 2015 , Jul 15. PMID:26176329 doi:http://dx.doi.org/10.1056/NEJMoa1504942
  3. ↑ Ferrer-Orta C, Perez-Sanchez MD, Coronado-Parra T, Silva C, Lopez-Martinez D, Baltanas-Copado J, Gomez-Fernandez JC, Corbalan-Garcia S, Verdaguer N. Structural characterization of the Rabphilin-3A-SNAP25 interaction. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5343-E5351. doi:, 10.1073/pnas.1702542114. Epub 2017 Jun 20. PMID:28634303 doi:http://dx.doi.org/10.1073/pnas.1702542114

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Michal Harel, Alexander Berchansky

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