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SARS-CoV-2 protein ORF8

From Proteopedia

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<SX viewer='molstar' load='' size='340' side='right' caption='' scene=''>
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<StructureSection load='6zct' size='350' frame='true' align='right' caption='Crystal structure of the SARS-CoV-2 Non-structural protein 10 (PDB: 6zct).' scene='84/842056/6zct_b-factors/2' />
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{{Theoretical_model}}
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<span class="text-red">This page needs updating. There are now two [[empirical models]] for ORF8: [[7jtl]] and [[7jx6]].</span>
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== Function ==
== Function ==
'''Open Reading Frame 8 (ORF8)'''
'''Open Reading Frame 8 (ORF8)'''
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[[Coronavirus_Disease 2019 (COVID-19)]]
[[Coronavirus_Disease 2019 (COVID-19)]]
__NOTOC__
__NOTOC__
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</StructureSection>
== References ==
== References ==
<references/>
<references/>

Revision as of 19:32, 12 February 2022

Crystal structure of the SARS-CoV-2 Non-structural protein 10 (PDB: 6zct).

Drag the structure with the mouse to rotate

Function

Open Reading Frame 8 (ORF8) [1][2]

Disease

ORF8 contributes to the virulence of SARS-CoV-2 in COVID-19[3].

Relevance

Structural highlights

See also

Coronavirus_Disease 2019 (COVID-19)

</StructureSection>

References

  1. ↑ Modeling of the SARS-COV-2 Genome
  2. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129
  3. ↑ Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH. Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2). pii: 2021785118. doi:, 10.1073/pnas.2021785118. PMID:33361333 doi:http://dx.doi.org/10.1073/pnas.2021785118

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Joel L. Sussman, Eric Martz, Jaime Prilusky

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