1dr9

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{{STRUCTURE_1dr9| PDB=1dr9 | SCENE= }}
{{STRUCTURE_1dr9| PDB=1dr9 | SCENE= }}
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'''CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)'''
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===CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)===
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==Overview==
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B7-1 (CD80) and B7-2 (CD86) are glycoproteins expressed on antigen-presenting cells. The binding of these molecules to the T cell homodimers CD28 and CTLA-4 (CD152) generates costimulatory and inhibitory signals in T cells, respectively. The crystal structure of the extracellular region of B7-1 (sB7-1), solved to 3 A resolution, consists of a novel combination of two Ig-like domains, one characteristic of adhesion molecules and the other previously seen only in antigen receptors. In the crystal lattice, sB7-1 unexpectedly forms parallel, 2-fold rotationally symmetric homodimers. Analytical ultracentrifugation reveals that sB7-1 also dimerizes in solution. The structural data suggest a mechanism whereby the avidity-enhanced binding of B7-1 and CTLA-4 homodimers, along with the relatively high affinity of these interactions, favors the formation of very stable inhibitory signaling complexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 10661405 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10661405}}
==About this Structure==
==About this Structure==
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[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
[[Category: Ig superfamily]]
[[Category: Ig superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:11:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:30:13 2008''

Revision as of 20:30, 30 June 2008

Image:1dr9.png

Template:STRUCTURE 1dr9

CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)

Template:ABSTRACT PUBMED 10661405

About this Structure

1DR9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and dimerization of a soluble form of B7-1., Ikemizu S, Gilbert RJ, Fennelly JA, Collins AV, Harlos K, Jones EY, Stuart DI, Davis SJ, Immunity. 2000 Jan;12(1):51-60. PMID:10661405

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