2q7c
From Proteopedia
(New page: 200px<br /> <applet load="2q7c" size="450" color="white" frame="true" align="right" spinBox="true" caption="2q7c, resolution 2.00Å" /> '''Crystal structure o...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2q7c. | + | [[Image:2q7c.jpg|left|200px]]<br /><applet load="2q7c" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2q7c" size=" | + | |
caption="2q7c, resolution 2.00Å" /> | caption="2q7c, resolution 2.00Å" /> | ||
'''Crystal structure of IQN17'''<br /> | '''Crystal structure of IQN17'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2Q7C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with CL and ACE as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2Q7C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=ACE:'>ACE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7C OCA]. |
==Reference== | ==Reference== | ||
| Line 23: | Line 22: | ||
[[Category: viral protein/viral protein inhibitor]] | [[Category: viral protein/viral protein inhibitor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:51:34 2008'' |
Revision as of 12:51, 23 January 2008
|
Crystal structure of IQN17
Overview
The HIV-1 gp41 protein promotes viral entry by mediating the fusion of, viral and cellular membranes. A prominent pocket on the surface of a, central trimeric coiled coil within gp41 was previously identified as a, potential target for drugs that inhibit HIV-1 entry. We designed a, peptide, IQN17, which properly presents this pocket. Utilizing IQN17 and, mirror-image phage display, we identified cyclic, D-peptide inhibitors of, HIV-1 infection that share a sequence motif. A 1.5 A cocrystal structure, of IQN17 in complex with a D-peptide, and NMR studies, show that conserved, residues of these inhibitors make intimate contact with the gp41 pocket., Our studies validate the pocket per se as a target for drug development., IQN17 and these D-peptide inhibitors are likely to be useful for, development and identification of a new class of orally bioavailable, anti-HIV drugs.
About this Structure
2Q7C is a Single protein structure of sequence from [1] with and as ligands. Full crystallographic information is available from OCA.
Reference
Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket., Eckert DM, Malashkevich VN, Hong LH, Carr PA, Kim PS, Cell. 1999 Oct 1;99(1):103-15. PMID:10520998
Page seeded by OCA on Wed Jan 23 14:51:34 2008
