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1ds5

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{{STRUCTURE_1ds5| PDB=1ds5 | SCENE= }}
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'''DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME.'''
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===DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME.===
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==Overview==
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The crystal structure of a complex between the catalytic alpha subunit of Zea mays CK2 and a 23-mer peptide corresponding the C-terminal sequence 181-203 of the human CK2 regulatory beta subunit has been determined at 3.16-A resolution. The complex, composed of two alpha chains and two peptides, presents a molecular twofold axis, with each peptide interacting with both alpha chains. In the derived model of the holoenzyme, the regulatory subunits are positioned on the opposite side with respect to the opening of the catalytic sites, that remain accessible to substrates and cosubstrates. The beta subunit can influence the catalytic activity both directly and by promoting the formation of the alpha2 dimer, in which each alpha chain interacts with the active site of the other. Furthermore, the two active sites are so close in space that they can simultaneously bind and phosphorylate two phosphoacceptor residues of the same substrate.
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(as it appears on PubMed at http://www.pubmed.gov), where 10931203 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10931203}}
==About this Structure==
==About this Structure==
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[[Category: Protein-complex]]
[[Category: Protein-complex]]
[[Category: Tetramer]]
[[Category: Tetramer]]
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Revision as of 20:32, 30 June 2008

Image:1ds5.png

Template:STRUCTURE 1ds5

DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME.

Template:ABSTRACT PUBMED 10931203

About this Structure

1DS5 is a Protein complex structure of sequences from Zea mays. Full crystallographic information is available from OCA.

Reference

The crystal structure of the complex of Zea mays alpha subunit with a fragment of human beta subunit provides the clue to the architecture of protein kinase CK2 holoenzyme., Battistutta R, Sarno S, De Moliner E, Marin O, Issinger OG, Zanotti G, Pinna LA, Eur J Biochem. 2000 Aug;267(16):5184-90. PMID:10931203

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