7keu
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer== |
| - | <StructureSection load='7keu' size='340' side='right'caption='[[7keu]]' scene=''> | + | <StructureSection load='7keu' size='340' side='right'caption='[[7keu]], [[Resolution|resolution]] 3.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7keu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KEU FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7keu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7keu OCA], [https://pdbe.org/7keu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7keu RCSB], [https://www.ebi.ac.uk/pdbsum/7keu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7keu ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7keu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7keu OCA], [https://pdbe.org/7keu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7keu RCSB], [https://www.ebi.ac.uk/pdbsum/7keu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7keu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Caspase 3D structures|Caspase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: David L]] |
| + | [[Category: Hollingsworth LR]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Ruan J]] | ||
| + | [[Category: Wu H]] | ||
Current revision
Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer
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Categories: Homo sapiens | Large Structures | David L | Hollingsworth LR | Li Y | Ruan J | Wu H
