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1b34

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CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN

Structural highlights

1b34 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.5Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SMD1_HUMAN May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F, and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs (snRNAs). These proteins share a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. Crystal structures of two Sm protein complexes, D3B and D1D2, show that these proteins have a common fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta sheet, and the D1D2 and D3B dimers superpose closely in their core regions, including the dimer interfaces. The crystal structures suggest that the seven Sm proteins could form a closed ring and the snRNAs may be bound in the positively charged central hole.

Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.,Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K Cell. 1999 Feb 5;96(3):375-87. PMID:10025403^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K. Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. Cell. 1999 Feb 5;96(3):375-87. PMID:10025403

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1b34"

@@ Line 3: / Line 3: @@
 <StructureSection load='1b34' size='340' side='right'caption='[[1b34]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1b34]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B34 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1b34]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B34 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b34 OCA], [https://pdbe.org/1b34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b34 RCSB], [https://www.ebi.ac.uk/pdbsum/1b34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b34 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b34 OCA], [https://pdbe.org/1b34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b34 RCSB], [https://www.ebi.ac.uk/pdbsum/1b34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b34 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/SMD1_HUMAN SMD1_HUMAN]] May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA. [[https://www.uniprot.org/uniprot/SMD2_HUMAN SMD2_HUMAN]] Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity).
+[https://www.uniprot.org/uniprot/SMD1_HUMAN SMD1_HUMAN] May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 36: / Line 37: @@
 [[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Avis, J M]]
+[[Category: Avis JM]]
-[[Category: Fortelle, E De La]]
+[[Category: De La Fortelle E]]
-[[Category: Kambach, C]]
+[[Category: Kambach C]]
-[[Category: Li, J]]
+[[Category: Li J]]
-[[Category: Nagai, K]]
+[[Category: Nagai K]]
-[[Category: Walke, S]]
+[[Category: Walke S]]
-[[Category: Young, R J]]
+[[Category: Young RJ]]
-[[Category: Core snrnp domain]]
-[[Category: Rna binding protein]]
-[[Category: Sle]]
-[[Category: Sm]]
-[[Category: Snrnp]]
-[[Category: Spliceosome]]
-[[Category: Splicing]]
-[[Category: Systemic lupus erythematosus]]

1b34

From Proteopedia

Current revision

CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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