This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

1b9w

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI

Structural highlights

1b9w is a 1 chain structure with sequence from Plasmodium cynomolgi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q25659_9APIC

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The C-terminal proteolytic processing product of merozoite surface protein 1 (MSP1) appears essential for successful erythrocyte invasion by the malarial parasite, Plasmodium. We have determined the crystal structure at 1.8 A resolution of a soluble baculovirus-recombinant form of the protein from P. cynomolgi, which confers excellent protective efficacy in primate vaccination trials. The structure comprises two EGF-like domains, and sequence comparisons strongly suggest that the same conformation is present in all species of Plasmodium, including P. falciparum and P. vivax, which are pathogenic in man. In particular, conserved interdomain contacts between the two EGF modules should preserve the compact form of the molecule in all species. Implications of the crystal structure for anti-malarial vaccine development are discussed.

The crystal structure of C-terminal merozoite surface protein 1 at 1.8 A resolution, a highly protective malaria vaccine candidate.,Chitarra V, Holm I, Bentley GA, Petres S, Longacre S Mol Cell. 1999 Apr;3(4):457-64. PMID:10230398^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chitarra V, Holm I, Bentley GA, Petres S, Longacre S. The crystal structure of C-terminal merozoite surface protein 1 at 1.8 A resolution, a highly protective malaria vaccine candidate. Mol Cell. 1999 Apr;3(4):457-64. PMID:10230398

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1b9w"

@@ Line 3: / Line 3: @@
 <StructureSection load='1b9w' size='340' side='right'caption='[[1b9w]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1b9w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B9W FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1b9w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_cynomolgi Plasmodium cynomolgi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B9W FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9w OCA], [https://pdbe.org/1b9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b9w RCSB], [https://www.ebi.ac.uk/pdbsum/1b9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b9w ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9w OCA], [https://pdbe.org/1b9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b9w RCSB], [https://www.ebi.ac.uk/pdbsum/1b9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b9w ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q25659_9APIC Q25659_9APIC]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 30: / Line 33: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Bentley, G A]]
+[[Category: Plasmodium cynomolgi]]
-[[Category: Chitarra, V]]
+[[Category: Bentley GA]]
-[[Category: Holm, I]]
+[[Category: Chitarra V]]
-[[Category: Longacre, S]]
+[[Category: Holm I]]
-[[Category: Candidate malaria vaccine]]
+[[Category: Longacre S]]
-[[Category: Msp-1]]
-[[Category: Surface antigen]]
-[[Category: Surface protein]]

1b9w

From Proteopedia

Current revision

C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox