2fe5
From Proteopedia
(Difference between revisions)
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<StructureSection load='2fe5' size='340' side='right'caption='[[2fe5]], [[Resolution|resolution]] 1.10Å' scene=''> | <StructureSection load='2fe5' size='340' side='right'caption='[[2fe5]], [[Resolution|resolution]] 1.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2fe5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2fe5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FE5 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fe5 OCA], [https://pdbe.org/2fe5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fe5 RCSB], [https://www.ebi.ac.uk/pdbsum/2fe5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fe5 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fe5 OCA], [https://pdbe.org/2fe5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fe5 RCSB], [https://www.ebi.ac.uk/pdbsum/2fe5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fe5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN] Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:[https://omim.org/entry/300850 300850]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:15185169</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | [[Category: Berridge | + | [[Category: Berridge G]] |
| - | [[Category: Bray | + | [[Category: Bray J]] |
| - | [[Category: Bunkoczi | + | [[Category: Bunkoczi G]] |
| - | [[Category: Colebrook | + | [[Category: Colebrook S]] |
| - | [[Category: Debreczeni | + | [[Category: Debreczeni J]] |
| - | + | [[Category: Doyle D]] | |
| - | [[Category: Doyle | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Elkins J]] |
| - | [[Category: Elkins | + | [[Category: Gorrec F]] |
| - | [[Category: Gorrec | + | [[Category: Phillips C]] |
| - | [[Category: Phillips | + | [[Category: Salah E]] |
| - | + | [[Category: Savitsky P]] | |
| - | [[Category: Salah | + | [[Category: Schoch G]] |
| - | [[Category: Savitsky | + | [[Category: Smee C]] |
| - | [[Category: Schoch | + | [[Category: Sundstrom M]] |
| - | [[Category: Smee | + | [[Category: Turnbull A]] |
| - | [[Category: Sundstrom | + | [[Category: Ugochukwu E]] |
| - | [[Category: Turnbull | + | [[Category: Weigelt J]] |
| - | [[Category: Ugochukwu | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
| - | [[Category: | + | |
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Current revision
The Crystal Structure of the Second PDZ Domain of Human DLG3
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Berridge G | Bray J | Bunkoczi G | Colebrook S | Debreczeni J | Doyle D | Edwards A | Elkins J | Gorrec F | Phillips C | Salah E | Savitsky P | Schoch G | Smee C | Sundstrom M | Turnbull A | Ugochukwu E | Weigelt J | Von Delft F
