Nuclear receptors
From Proteopedia
(Difference between revisions)
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'''Family members (~ according to [https://en.wikipedia.org/wiki/Nuclear_receptor]):''' | '''Family members (~ according to [https://en.wikipedia.org/wiki/Nuclear_receptor]):''' | ||
=Thyroid Hormone Receptor-like= | =Thyroid Hormone Receptor-like= | ||
| - | ==[[Thyroid hormone receptor]]== | + | ==Thyroid hormone receptor== |
| - | ==[[Retinoic acid receptor]] | + | *[[Thyroid hormone receptor]] |
| - | + | ==Retinoic acid receptor== | |
| + | *[[Retinoic acid receptor]] | ||
| + | *[[RA Mediated T-reg Differentiation]]; Retinoic acid acts as the ligand for the Retinoic Acid Receptor-α (RARα) / Retinoid X Receptor-α (RXRα) heterodimer | ||
==[[Peroxisome Proliferator-Activated Receptors]]== | ==[[Peroxisome Proliferator-Activated Receptors]]== | ||
===PPARγ=== | ===PPARγ=== | ||
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* When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA (see below). | * When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA (see below). | ||
=Retinoid X Receptor-like= | =Retinoid X Receptor-like= | ||
| - | ==[[Retinoid X receptor]] | + | ==Retinoid X receptor== |
| - | + | *[[Retinoid X receptor]] | |
| + | *[[RA Mediated T-reg Differentiation]]; Retinoic acid acts as the ligand for the Retinoic Acid Receptor-α (RARα) / Retinoid X Receptor-α (RXRα) heterodimer | ||
= Estrogen Receptor-like= | = Estrogen Receptor-like= | ||
| - | ==[[Estrogen receptor]] | + | ==Estrogen receptor== |
| + | *[[Estrogen receptor]] | ||
* [[Ivan Koutsopatriy estrogen receptor]] | * [[Ivan Koutsopatriy estrogen receptor]] | ||
===Estrogen receptor alpha=== | ===Estrogen receptor alpha=== | ||
Revision as of 12:42, 3 March 2021
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References
- ↑ Bohl CE, Wu Z, Chen J, Mohler ML, Yang J, Hwang DJ, Mustafa S, Miller DD, Bell CE, Dalton JT. Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5567-70. Epub 2008 Sep 5. PMID:18805694 doi:10.1016/j.bmcl.2008.09.002
- ↑ Li MJ, Greenblatt HM, Dym O, Albeck S, Pais A, Gunanathan C, Milstein D, Degani H, Sussman JL. Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators. J Med Chem. 2011 Apr 7. PMID:21473635 doi:10.1021/jm200192y
