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==Iduronate 2-sulfatase== | ==Iduronate 2-sulfatase== | ||
<StructureSection load='5FQL' size='340' side='right' caption='Iduronate 2-sulfatase protein' scene=''> | <StructureSection load='5FQL' size='340' side='right' caption='Iduronate 2-sulfatase protein' scene=''> | ||
| - | + | Iduronate 2-sulfatase (I2S), also referred to as Alpha-L-iduronate sulfate sulfatase or Idursulfase, is a lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.[1] | |
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[[Image:MW_Folding_Simulations.gif]] | [[Image:MW_Folding_Simulations.gif]] | ||
== Function == | == Function == | ||
| - | Iduronate 2-sulfatase is involved in the degradation pathway of dermatan sulfate and heparan sulfate. | + | Iduronate 2-sulfatase is located in the lysosome.[1] It is involved in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate.[1] I2S hydrolyzes the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.[1] Dermatan sulfate and heparan sulfate are complex glycosaminoglycans, which are essentially large sugar molecules.[2] They play important roles in cell adhesion, growth, proliferation and repair, and their degradation and recycling in the lysosome are essential for cellular maintenance.[2] |
== Relevance == | == Relevance == | ||
Revision as of 20:51, 27 April 2021
Iduronate 2-sulfatase
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