1dt6

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{{STRUCTURE_1dt6| PDB=1dt6 | SCENE= }}
{{STRUCTURE_1dt6| PDB=1dt6 | SCENE= }}
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'''STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5'''
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===STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5===
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==Overview==
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Microsomal cytochrome P450s participate in xenobiotic detoxification, procarcinogen activation, and steroid hormone synthesis. The first structure of a mammalian microsomal P450 suggests that the association of P450s with the endoplasmic reticulum involves a hydrophobic surface of the protein formed by noncontiguous portions of the polypeptide chain. This interaction places the entrance of the putative substrate access channel in or near the membrane and orients the face of the protein proximal to the heme cofactor perpendicular to the plane of the membrane for interaction with the P450 reductase. This structure offers a template for modeling other mammalian P450s and should aid drug discovery and the prediction of drug-drug interactions.
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{{ABSTRACT_PUBMED_10678174}}
==About this Structure==
==About this Structure==
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[[Category: P450]]
[[Category: P450]]
[[Category: Progesterone 21-hydroxylase]]
[[Category: Progesterone 21-hydroxylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:34:58 2008''

Revision as of 20:34, 30 June 2008

Image:1dt6.png

Template:STRUCTURE 1dt6

STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5

Template:ABSTRACT PUBMED 10678174

About this Structure

1DT6 is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity., Williams PA, Cosme J, Sridhar V, Johnson EF, McRee DE, Mol Cell. 2000 Jan;5(1):121-31. PMID:10678174

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