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1dtp

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{{STRUCTURE_1dtp| PDB=1dtp | SCENE= }}
{{STRUCTURE_1dtp| PDB=1dtp | SCENE= }}
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'''THE STRUCTURE OF THE ISOLATED CATALYTIC DOMAIN OF DIPHTHERIA TOXIN'''
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===THE STRUCTURE OF THE ISOLATED CATALYTIC DOMAIN OF DIPHTHERIA TOXIN===
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==Overview==
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The structure of the isolated catalytic domain of diphtheria toxin at pH 5.0 was determined by X-ray crystallography at 2.5 A resolution and refined to an R-factor of 19.7%. The domain is bound to its endogenous inhibitor adenylyl(3'--&gt;5')uridine 3'-monophosphate (ApUp). The structure of this 190-residue domain, which was expressed in and isolated from Escherichia coli, is essentially identical to the structure of the catalytic domain within whole diphtheria toxin determined at pH 7.5. However, there are two adjacent surface loops (loop 66-78 and loop 169-176) that exhibit clear differences when compared to the structure of the catalytic domain in whole diphtheria toxin. Although both loops are at the surface of the protein and are relatively flexible, the chain trace is well-defined in the electron density. The main structural difference is the closer approach of loops 66-78 and 169-176. We ascribe this structural change mainly to the absence of the neighboring transmembrane domain in the isolated catalytic domain as compared to whole diphtheria toxin. We suggest that this change represents the first step of the structural transition from the catalytic domain in whole diphtheria toxin to the translocated form of the domain. The changes are described in detail, and their implications for membrane translocation are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 7827036 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7827036}}
==About this Structure==
==About this Structure==
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[[Category: Weiss, M S.]]
[[Category: Weiss, M S.]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:15:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:36:09 2008''

Revision as of 20:36, 30 June 2008

Image:1dtp.png

Template:STRUCTURE 1dtp

THE STRUCTURE OF THE ISOLATED CATALYTIC DOMAIN OF DIPHTHERIA TOXIN

Template:ABSTRACT PUBMED 7827036

About this Structure

1DTP is a Single protein structure of sequence from Corynephage beta. Full crystallographic information is available from OCA.

Reference

Structure of the isolated catalytic domain of diphtheria toxin., Weiss MS, Blanke SR, Collier RJ, Eisenberg D, Biochemistry. 1995 Jan 24;34(3):773-81. PMID:7827036

Page seeded by OCA on Mon Jun 30 23:36:09 2008

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