This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7bj1
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of SMYD3 with diperodon S enantiomer bound to allosteric site== | ==Crystal structure of SMYD3 with diperodon S enantiomer bound to allosteric site== | ||
| - | <StructureSection load='7bj1' size='340' side='right'caption='[[7bj1]]' scene=''> | + | <StructureSection load='7bj1' size='340' side='right'caption='[[7bj1]], [[Resolution|resolution]] 1.61Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6z2r 6z2r]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BJ1 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7bj1]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6z2r 6z2r]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BJ1 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bj1 OCA], [https://pdbe.org/7bj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bj1 RCSB], [https://www.ebi.ac.uk/pdbsum/7bj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bj1 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QKT:Diperodon+(S-enantiomer)'>QKT</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/[Histone_H3]-lysine(4)_N-trimethyltransferase [Histone H3]-lysine(4) N-trimethyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.354 2.1.1.354] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bj1 OCA], [https://pdbe.org/7bj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bj1 RCSB], [https://www.ebi.ac.uk/pdbsum/7bj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bj1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN]] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Danielson | + | [[Category: Danielson, U H]] |
| - | [[Category: Dobritzsch D]] | + | [[Category: Dobritzsch, D]] |
| - | [[Category: Eriksson D]] | + | [[Category: Eriksson, D]] |
| - | [[Category: Talibov | + | [[Category: Talibov, V O]] |
| + | [[Category: Complex]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Methyltransferase]] | ||
| + | [[Category: Oncoprotein]] | ||
Revision as of 17:55, 10 March 2021
Crystal structure of SMYD3 with diperodon S enantiomer bound to allosteric site
| |||||||||||
