6y1s
From Proteopedia
(Difference between revisions)
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==Bicyclic peptide bp70 in I4132 at 1.0 Angstrom resolution== | ==Bicyclic peptide bp70 in I4132 at 1.0 Angstrom resolution== | ||
| - | <StructureSection load='6y1s' size='340' side='right'caption='[[6y1s]]' scene=''> | + | <StructureSection load='6y1s' size='340' side='right'caption='[[6y1s]], [[Resolution|resolution]] 1.04Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y1S FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6y1s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y1S FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y1s OCA], [https://pdbe.org/6y1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y1s RCSB], [https://www.ebi.ac.uk/pdbsum/6y1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y1s ProSAT]</span></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAB:2,4-DIAMINOBUTYRIC+ACID'>DAB</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=O65:'>O65</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y1s OCA], [https://pdbe.org/6y1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y1s RCSB], [https://www.ebi.ac.uk/pdbsum/6y1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y1s ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The peptide alpha-helix is right-handed when containing amino acids with l-chirality, and left-handed with d-chirality, however mixed chirality peptides generally do not form alpha-helices unless a helix inducer such as the non-natural residue amino-isobutyric acid is used. Herein we report the first X-ray crystal structures of mixed chirality alpha-helices in short peptides comprising only natural residues as the example of a stapled bicyclic and a linear membrane disruptive amphiphilic antimicrobial peptide (AMP) containing seven l- and four d-residues, as complexes of fucosylated analogs with the bacterial lectin LecB. The mixed chirality alpha-helices are superimposable onto the homochiral alpha-helices and form under similar conditions as shown by CD spectra and MD simulations but non-hemolytic and resistant to proteolysis. The observation of a mixed chirality alpha-helix with only natural residues in the protein environment of LecB suggests a vast unexplored territory of alpha-helical mixed chirality sequences and their possible use for optimizing bioactive alpha-helical peptides. | ||
| + | |||
| + | A mixed chirality alpha-helix in a stapled bicyclic and a linear antimicrobial peptide revealed by X-ray crystallography.,Baeriswyl S, Personne H, Di Bonaventura I, Kohler T, van Delden C, Stocker A, Javor S, Reymond JL RSC Chem Biol. 2021 Aug 20;2(6):1608-1617. doi: 10.1039/d1cb00124h. eCollection, 2021 Dec 2. PMID:34977576<ref>PMID:34977576</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6y1s" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Baeriswyl S]] | + | [[Category: Baeriswyl, S]] |
| - | [[Category: Reymond J | + | [[Category: Reymond, J L]] |
| - | [[Category: Stocker A]] | + | [[Category: Stocker, A]] |
| + | [[Category: Antibiotic]] | ||
| + | [[Category: Antimicrobial]] | ||
| + | [[Category: Bicyclic]] | ||
| + | [[Category: Lectin]] | ||
Revision as of 07:07, 2 February 2022
Bicyclic peptide bp70 in I4132 at 1.0 Angstrom resolution
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