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1cw0

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Current revision (05:54, 9 August 2023) (edit) (undo)
 
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<StructureSection load='1cw0' size='340' side='right'caption='[[1cw0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1cw0' size='340' side='right'caption='[[1cw0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1cw0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CW0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1cw0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CW0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw0 OCA], [https://pdbe.org/1cw0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cw0 RCSB], [https://www.ebi.ac.uk/pdbsum/1cw0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cw0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw0 OCA], [https://pdbe.org/1cw0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cw0 RCSB], [https://www.ebi.ac.uk/pdbsum/1cw0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cw0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/VSR_ECOLI VSR_ECOLI]] Deamination of 5-methylcytosine in DNA results in T/G mismatches. If unrepaired, these mismatches can lead to C-to-C transition mutations. The very short patch (VSP) repair process in E.coli counteracts the mutagenic process by repairing the mismatches in favor of the G-containing strand. This enzyme is an endonuclease that nicks double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the thymidine residue that is mismatched to 2'-deoxyguanosine. The incision is mismatch-dependent and strand-specific.
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[https://www.uniprot.org/uniprot/VSR_ECOLI VSR_ECOLI] Deamination of 5-methylcytosine in DNA results in T/G mismatches. If unrepaired, these mismatches can lead to C-to-C transition mutations. The very short patch (VSP) repair process in E.coli counteracts the mutagenic process by repairing the mismatches in favor of the G-containing strand. This enzyme is an endonuclease that nicks double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the thymidine residue that is mismatched to 2'-deoxyguanosine. The incision is mismatch-dependent and strand-specific.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Jingami, H]]
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[[Category: Jingami H]]
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[[Category: Morikawa, K]]
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[[Category: Morikawa K]]
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[[Category: Tsutakawa, S E]]
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[[Category: Tsutakawa SE]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Hydrolase/dna]]
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[[Category: Intercalation]]
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[[Category: Mismatch]]
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[[Category: Protein-dna complex]]
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[[Category: Zinc]]
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Current revision

CRYSTAL STRUCTURE ANALYSIS OF VERY SHORT PATCH REPAIR (VSR) ENDONUCLEASE IN COMPLEX WITH A DUPLEX DNA

PDB ID 1cw0

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