1e9l
From Proteopedia
(Difference between revisions)
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==The crystal structure of novel mammalian lectin Ym1 suggests a saccharide binding site== | ==The crystal structure of novel mammalian lectin Ym1 suggests a saccharide binding site== | ||
| - | <StructureSection load='1e9l' size='340' side='right'caption='[[1e9l]]' scene=''> | + | <StructureSection load='1e9l' size='340' side='right'caption='[[1e9l]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E9L FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1e9l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E9L FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e9l OCA], [https://pdbe.org/1e9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e9l RCSB], [https://www.ebi.ac.uk/pdbsum/1e9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e9l ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCS:D-GLUCOSAMINE'>GCS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e9l OCA], [https://pdbe.org/1e9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e9l RCSB], [https://www.ebi.ac.uk/pdbsum/1e9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e9l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CHIL3_MOUSE CHIL3_MOUSE] Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy.<ref>PMID:10625674</ref> <ref>PMID:11297523</ref> <ref>PMID:11733538</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e9l ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e9l ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
[[Category: Hsiao CD]] | [[Category: Hsiao CD]] | ||
[[Category: Sun YJ]] | [[Category: Sun YJ]] | ||
Revision as of 10:00, 20 March 2024
The crystal structure of novel mammalian lectin Ym1 suggests a saccharide binding site
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