1duz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1duz.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1duz.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1duz| PDB=1duz | SCENE= }}
{{STRUCTURE_1duz| PDB=1duz | SCENE= }}
-
'''HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A 0201) IN COMPLEX WITH A NONAMERIC PEPTIDE FROM HTLV-1 TAX PROTEIN'''
+
===HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A 0201) IN COMPLEX WITH A NONAMERIC PEPTIDE FROM HTLV-1 TAX PROTEIN===
-
==Overview==
+
<!--
-
The crystal structure of the human class I MHC molecule HLA-A2 complexed with of an octameric peptide, Tax8 (LFGYPVYV), from human T cell lymphotrophic virus-1 (HTLV-1) has been determined. This structure is compared with a newly refined, higher resolution (1.8 A) structure of HLA-A2 complexed with the nonameric Tax9 peptide (LLFGYPVYV) with one more N-terminal residue. Despite the absence of a peptide residue (P1) bound in the conserved N-terminal peptide-binding pocket of the Tax8/HLA-A2 complex, the structures of the two complexes are essentially identical. Water molecules in the Tax8 complex replace the terminal amino group of the Tax9 peptide and mediate a network of hydrogen bonds among the secondary structural elements at that end of the peptide-binding groove. Thermal denaturation measurements indicate that the Tax8 complex is much less stable, DeltaTm = 16 degrees C, than the Tax9 complex, but both can sensitize target cells for lysis by some Tax-specific CTL from HTLV-1 infected individuals. The absence of a P1 peptide residue is thus not enough to prevent formation of a "closed conformation" of the peptide-binding site. TCR affinity measurements and cytotoxic T cell assays indicate that the Tax8/HLA-A2 complex does not functionally cross-react with the A6-TCR-bearing T cell clone specific for Tax9/HLA-A2 complexes.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10843695}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10843695 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10843695}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:18:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:39:30 2008''

Revision as of 20:39, 30 June 2008

Image:1duz.png

Template:STRUCTURE 1duz

HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A 0201) IN COMPLEX WITH A NONAMERIC PEPTIDE FROM HTLV-1 TAX PROTEIN

Template:ABSTRACT PUBMED 10843695

About this Structure

1DUZ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure and stability of an HLA-A*0201/octameric tax peptide complex with an empty conserved peptide-N-terminal binding site., Khan AR, Baker BM, Ghosh P, Biddison WE, Wiley DC, J Immunol. 2000 Jun 15;164(12):6398-405. PMID:10843695

Page seeded by OCA on Mon Jun 30 23:39:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1duz"
Personal tools