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1dvi

From Proteopedia

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[[Image:1dvi.gif|left|200px]]
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{{STRUCTURE_1dvi| PDB=1dvi | SCENE= }}
{{STRUCTURE_1dvi| PDB=1dvi | SCENE= }}
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'''CALPAIN DOMAIN VI WITH CALCIUM BOUND'''
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===CALPAIN DOMAIN VI WITH CALCIUM BOUND===
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==Overview==
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The crystal structure of a Ca(2+)-binding domain (dVI) of rat m-calpain has been determined at 2.3 A resolution, both with and without bound Ca2+. The structures reveal a unique fold incorporating five EF-hand motifs per monomer, three of which bind calcium at physiological calcium concentrations, with one showing a novel EF-hand coordination pattern. This investigation gives us a first view of the calcium-induced conformational changes, and consequently an insight into the mechanism of calcium induced activation in calpain. The crystal structures reveal a dVI homodimer which provides a preliminary model for the subunit dimerization in calpain.
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The line below this paragraph, {{ABSTRACT_PUBMED_9228945}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9228945 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9228945}}
==About this Structure==
==About this Structure==
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[[Category: Calcium-dependent protease]]
[[Category: Calcium-dependent protease]]
[[Category: Small subunit]]
[[Category: Small subunit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:19:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:40:56 2008''

Revision as of 20:40, 30 June 2008

Image:1dvi.png

Template:STRUCTURE 1dvi

CALPAIN DOMAIN VI WITH CALCIUM BOUND

Template:ABSTRACT PUBMED 9228945

About this Structure

1DVI is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes., Blanchard H, Grochulski P, Li Y, Arthur JS, Davies PL, Elce JS, Cygler M, Nat Struct Biol. 1997 Jul;4(7):532-8. PMID:9228945

Page seeded by OCA on Mon Jun 30 23:40:56 2008

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