4rsz

Structural highlights

Function

CYC_HORSE Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).

See Also

• Cytochrome C 3D structures

References

1. ↑ Ferraro G, Messori L, Merlino A. The X-ray structure of the primary adducts formed in the reaction between cisplatin and cytochrome c. Chem Commun (Camb). 2015 Jan 29;51(13):2559-61. doi: 10.1039/c4cc09056j. PMID:25567806 doi:http://dx.doi.org/10.1039/c4cc09056j