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7a62

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Current revision (12:04, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7a62' size='340' side='right'caption='[[7a62]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
<StructureSection load='7a62' size='340' side='right'caption='[[7a62]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7a62]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6tue 6tue]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A62 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7a62]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6tue 6tue]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A62 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4379644&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IDO1, IDO, INDO ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Indoleamine_2,3-dioxygenase Indoleamine 2,3-dioxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.52 1.13.11.52] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a62 OCA], [https://pdbe.org/7a62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a62 RCSB], [https://www.ebi.ac.uk/pdbsum/7a62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a62 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a62 OCA], [https://pdbe.org/7a62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a62 RCSB], [https://www.ebi.ac.uk/pdbsum/7a62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a62 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/I23O1_HUMAN I23O1_HUMAN]] Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.<ref>PMID:17671174</ref>
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[https://www.uniprot.org/uniprot/I23O1_HUMAN I23O1_HUMAN] Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.<ref>PMID:17671174</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Indoleamine 2,3-dioxygenase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mirgaux, M]]
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[[Category: Mirgaux M]]
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[[Category: Wouters, J]]
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[[Category: Wouters J]]
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[[Category: Dioxygenase]]
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[[Category: Enzyme]]
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[[Category: Heme-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Tryptophan catabolism]]
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Current revision

Structure of human indoleamine-2,3-dioxygenase 1 (hIDO1) with a complete JK loop

PDB ID 7a62

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