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1d8a

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Current revision (06:50, 7 February 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1d8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D8A FirstGlance]. <br>
<table><tr><td colspan='2'>[[1d8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D8A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d8a OCA], [https://pdbe.org/1d8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d8a RCSB], [https://www.ebi.ac.uk/pdbsum/1d8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d8a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d8a OCA], [https://pdbe.org/1d8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d8a RCSB], [https://www.ebi.ac.uk/pdbsum/1d8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d8a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI]] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>
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[https://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baker, P J]]
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[[Category: Baker PJ]]
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[[Category: Levy, C W]]
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[[Category: Levy CW]]
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[[Category: Rafferty, J B]]
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[[Category: Rafferty JB]]
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[[Category: Rice, D W]]
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[[Category: Rice DW]]
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[[Category: Roujeinikova, A]]
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[[Category: Roujeinikova A]]
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[[Category: Sedelnikova, S]]
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[[Category: Sedelnikova S]]
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[[Category: Slabas, A R]]
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[[Category: Slabas AR]]
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[[Category: Stuitje, A R]]
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[[Category: Stuitje AR]]
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[[Category: E. coli enoyl reductase]]
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[[Category: Oxidoreductase]]
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[[Category: Triclosan]]
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Current revision

E. COLI ENOYL REDUCTASE/NAD+/TRICLOSAN COMPLEX

PDB ID 1d8a

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