1dm8
From Proteopedia
(Difference between revisions)
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<StructureSection load='1dm8' size='340' side='right'caption='[[1dm8]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='1dm8' size='340' side='right'caption='[[1dm8]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1dm8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DM8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1dm8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DM8 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TZC:1,2,4-TRIAZOLE-CARBOXAMIDINE'>TZC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TZC:1,2,4-TRIAZOLE-CARBOXAMIDINE'>TZC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dm8 OCA], [https://pdbe.org/1dm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dm8 RCSB], [https://www.ebi.ac.uk/pdbsum/1dm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dm8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dm8 OCA], [https://pdbe.org/1dm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dm8 RCSB], [https://www.ebi.ac.uk/pdbsum/1dm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dm8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Li | + | [[Category: Li H]] |
| - | [[Category: Martasek | + | [[Category: Martasek P]] |
| - | [[Category: Masters | + | [[Category: Masters BSS]] |
| - | [[Category: Poulos | + | [[Category: Poulos TL]] |
| - | [[Category: Raman | + | [[Category: Raman CS]] |
| - | [[Category: Southan | + | [[Category: Southan GJ]] |
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Current revision
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,2,4-TRIAZOLE-CARBOXAMIDINE (H4B BOUND)
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Categories: Bos taurus | Large Structures | Li H | Martasek P | Masters BSS | Poulos TL | Raman CS | Southan GJ
