2gjs

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Current revision (09:28, 14 February 2024) (edit) (undo)
 
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<StructureSection load='2gjs' size='340' side='right'caption='[[2gjs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2gjs' size='340' side='right'caption='[[2gjs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2gjs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2gjs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RRAD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjs OCA], [https://pdbe.org/2gjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjs RCSB], [https://www.ebi.ac.uk/pdbsum/2gjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjs OCA], [https://pdbe.org/2gjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjs RCSB], [https://www.ebi.ac.uk/pdbsum/2gjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RAD_HUMAN RAD_HUMAN]] May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.<ref>PMID:18056528</ref>
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[https://www.uniprot.org/uniprot/RAD_HUMAN RAD_HUMAN] May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.<ref>PMID:18056528</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Arrowsmith C]]
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[[Category: Berridge, G]]
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[[Category: Berridge G]]
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[[Category: Bray, J]]
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[[Category: Bray J]]
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[[Category: Burgess, N]]
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[[Category: Burgess N]]
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[[Category: Debreczeni, J]]
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[[Category: Debreczeni J]]
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[[Category: Delft, F von]]
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[[Category: Doyle D]]
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[[Category: Doyle, D]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, C]]
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[[Category: Pantic N]]
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[[Category: Pantic, N]]
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[[Category: Schoch G]]
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[[Category: Structural genomic]]
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[[Category: Smee CEA]]
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[[Category: Schoch, G]]
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[[Category: Soundararajan M]]
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[[Category: Smee, C E.A]]
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[[Category: Sundstrom M]]
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[[Category: Soundararajan, M]]
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[[Category: Turnbull AP]]
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[[Category: Sundstrom, M]]
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[[Category: Weigelt J]]
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[[Category: Turnbull, A P]]
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[[Category: Yang X]]
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[[Category: Weigelt, J]]
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[[Category: Von Delft F]]
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[[Category: Yang, X]]
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[[Category: Gdp/gtp binding]]
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[[Category: Gtp hydrolysis]]
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[[Category: Rrad]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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Current revision

The crystal structure of human RRAD in complex with GDP

PDB ID 2gjs

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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