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Aminoacyl tRNA Synthetase
From Proteopedia
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== 3D Structures of Aminoacyl tRNA synthetase == | == 3D Structures of Aminoacyl tRNA synthetase == | ||
[[Aminoacyl tRNA synthetase 3D structures]] | [[Aminoacyl tRNA synthetase 3D structures]] | ||
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| + | One very interesting question in biology is how does an aminoacyl-tRNA synthetase recognize a particular tRNA and charge it with the correct amino acid? This is a challenging problem, since all tRNAs have the same general structure. Interestingly, different tRNA synthetases accomplish this goal in different ways. | ||
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| + | The <scene name='44/444597/Protein_surface_interaction/1'>glutaminyl-tRNA synthetase</scene> (GlnRS) interacts with both the anticodon loop and the acceptor stem. Genetic and biochemical data indicate that GlnRS interacts with all three bases of the <scene name='44/444597/Anticodon_loop/1'>anticodon loop</scene>, which are unstacked and splay outward so they can bind in separate recognition pockets of GlnRS. The 3' end of tRNAgln plunges deeply into a protein pocket that also binds the enzymes ATP and glutamine substrates. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 19:29, 21 September 2021
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References
- ↑ Cavarelli J, Moras D. Recognition of tRNAs by aminoacyl-tRNA synthetases. FASEB J. 1993 Jan;7(1):79-86. PMID:8422978
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