1dws

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{{STRUCTURE_1dws| PDB=1dws | SCENE= }}
{{STRUCTURE_1dws| PDB=1dws | SCENE= }}
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'''PHOTOLYZED CARBONMONOXY MYOGLOBIN (HORSE HEART)'''
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===PHOTOLYZED CARBONMONOXY MYOGLOBIN (HORSE HEART)===
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==Overview==
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Small molecules such as NO, O2, CO or H2 are important biological ligands that bind to metalloproteins to function crucially in processes such as signal transduction, respiration and catalysis. A key issue for understanding the regulation of reaction mechanisms in these systems is whether ligands gain access to the binding sites through specific channels and docking sites, or by random diffusion through the protein matrix. A model system for studying this issue is myoglobin, a simple haem protein. Myoglobin has been studied extensively by spectroscopy, crystallography, computation and theory. It serves as an aid to oxygen diffusion but also binds carbon monoxide, a byproduct of endogenous haem catabolism. Molecular dynamics simulations, random mutagenesis and flash photolysis studies indicate that ligand migration occurs through a limited number of pathways involving docking sites. Here we report the 1.4 A resolution crystal structure of a ligand-binding intermediate in carbonmonoxy myoglobin that may have far-reaching implications for understanding the dynamics of ligand binding and catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 10706294 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10706294}}
==About this Structure==
==About this Structure==
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[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
[[Category: Respiratory protein]]
[[Category: Respiratory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:22:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:44:07 2008''

Revision as of 20:44, 30 June 2008

Image:1dws.png

Template:STRUCTURE 1dws

PHOTOLYZED CARBONMONOXY MYOGLOBIN (HORSE HEART)

Template:ABSTRACT PUBMED 10706294

About this Structure

1DWS is a Single protein structure of sequence from Equus caballus. Full crystallographic information is available from OCA.

Reference

Structure of a ligand-binding intermediate in wild-type carbonmonoxy myoglobin., Chu K, Vojtchovsky J, McMahon BH, Sweet RM, Berendzen J, Schlichting I, Nature. 2000 Feb 24;403(6772):921-3. PMID:10706294

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