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1dy2

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[[Image:1dy2.gif|left|200px]]
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{{STRUCTURE_1dy2| PDB=1dy2 | SCENE= }}
{{STRUCTURE_1dy2| PDB=1dy2 | SCENE= }}
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'''MURINE COLLAGEN ALPHA1(XV), ENDOSTATIN DOMAIN'''
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===MURINE COLLAGEN ALPHA1(XV), ENDOSTATIN DOMAIN===
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==Overview==
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Endostatin is a fragment of the C-terminal domain NC1 of collagen XVIII that inhibits angiogenesis and tumor growth. We report the characterization of a collagen XV endostatin analogue and its parent NC1 domain, obtained by recombinant expression in mammalian cells. Both NC1 domains contain a trimerization domain, a hinge region that is more sensitive to proteolysis in collagen XVIII and the endostatin domain. Unlike endostatin-XVIII, endostatin-XV does not bind zinc or heparin, which is explained by the crystal structure of endostatin-XV. The collagen XV and XVIII fragments inhibited chorioallantoic membrane angiogenesis induced by basic fibroblast growth factor (FGF-2) or vascular endothelial growth factor (VEGF), but there are striking differences depending on which cytokine is used and whether free endostatins or NC1 domains are applied. The collagen XV and XVIII fragments showed a similar binding repertoire for extracellular matrix proteins. Differences were found in the immunohistological localization in vessel walls and basement membrane zones. Together, these data indentify endostatin-XV as an angiogenesis inhibitor, which differs from endostatin-XVIII in several important functional details.
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The line below this paragraph, {{ABSTRACT_PUBMED_10966814}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10966814 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10966814}}
==About this Structure==
==About this Structure==
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[[Category: Tisi, D.]]
[[Category: Tisi, D.]]
[[Category: Angiogenesis inhibitor]]
[[Category: Angiogenesis inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:25:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:47:39 2008''

Revision as of 20:47, 30 June 2008

Image:1dy2.png

Template:STRUCTURE 1dy2

MURINE COLLAGEN ALPHA1(XV), ENDOSTATIN DOMAIN

Template:ABSTRACT PUBMED 10966814

About this Structure

1DY2 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity., Sasaki T, Larsson H, Tisi D, Claesson-Welsh L, Hohenester E, Timpl R, J Mol Biol. 2000 Sep 1;301(5):1179-90. PMID:10966814

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