1epf
From Proteopedia
(Difference between revisions)
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<StructureSection load='1epf' size='340' side='right'caption='[[1epf]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='1epf' size='340' side='right'caption='[[1epf]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1epf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EPF FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1epf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EPF FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1epf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epf OCA], [https://pdbe.org/1epf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1epf RCSB], [https://www.ebi.ac.uk/pdbsum/1epf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1epf ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1epf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epf OCA], [https://pdbe.org/1epf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1epf RCSB], [https://www.ebi.ac.uk/pdbsum/1epf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1epf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/NCAM1_RAT NCAM1_RAT] This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1epf ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1epf ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM. | ||
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| - | Structural basis of cell-cell adhesion by NCAM.,Kasper C, Rasmussen H, Kastrup JS, Ikemizu S, Jones EY, Berezin V, Bock E, Larsen IK Nat Struct Biol. 2000 May;7(5):389-93. PMID:10802736<ref>PMID:10802736</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1epf" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Berezin | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Bock | + | [[Category: Berezin V]] |
| - | [[Category: Ikemizu | + | [[Category: Bock E]] |
| - | [[Category: Jones | + | [[Category: Ikemizu S]] |
| - | [[Category: Kasper | + | [[Category: Jones EY]] |
| - | [[Category: Kastrup | + | [[Category: Kasper C]] |
| - | [[Category: Larsen | + | [[Category: Kastrup JS]] |
| - | [[Category: Rasmussen | + | [[Category: Larsen IK]] |
| - | + | [[Category: Rasmussen H]] | |
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Revision as of 10:04, 20 March 2024
CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)
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Categories: Large Structures | Rattus norvegicus | Berezin V | Bock E | Ikemizu S | Jones EY | Kasper C | Kastrup JS | Larsen IK | Rasmussen H
