This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2h1s
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='2h1s' size='340' side='right'caption='[[2h1s]], [[Resolution|resolution]] 2.45Å' scene=''> | <StructureSection load='2h1s' size='340' side='right'caption='[[2h1s]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2h1s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2h1s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H1S FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | <tr id=' | + | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h1s OCA], [https://pdbe.org/2h1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h1s RCSB], [https://www.ebi.ac.uk/pdbsum/2h1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h1s ProSAT], [https://www.topsan.org/Proteins/CESG/2h1s TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h1s OCA], [https://pdbe.org/2h1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h1s RCSB], [https://www.ebi.ac.uk/pdbsum/2h1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h1s ProSAT], [https://www.topsan.org/Proteins/CESG/2h1s TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/GRHPR_HUMAN GRHPR_HUMAN] Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:[https://omim.org/entry/260000 260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.<ref>PMID:10484776</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/GRHPR_HUMAN GRHPR_HUMAN] Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 27: | Line 26: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bingman | + | [[Category: Bingman CA]] |
| - | [[Category: Bitto | + | [[Category: Bitto E]] |
| - | + | [[Category: Phillips Jr GN]] | |
| - | [[Category: Phillips | + | [[Category: Wesenberg GE]] |
| - | [[Category: Wesenberg | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens
| |||||||||||
