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2hdc

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Current revision (00:07, 28 December 2023) (edit) (undo)
 
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==STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX==
==STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX==
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<StructureSection load='2hdc' size='340' side='right'caption='[[2hdc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2hdc' size='340' side='right'caption='[[2hdc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2hdc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HDC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2hdc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HDC FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GENESIS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hdc OCA], [https://pdbe.org/2hdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hdc RCSB], [https://www.ebi.ac.uk/pdbsum/2hdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hdc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hdc OCA], [https://pdbe.org/2hdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hdc RCSB], [https://www.ebi.ac.uk/pdbsum/2hdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hdc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FOXD3_RAT FOXD3_RAT]] Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (By similarity).
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[https://www.uniprot.org/uniprot/FOXD3_RAT FOXD3_RAT] Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, X]]
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[[Category: Rattus norvegicus]]
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[[Category: Jin, C]]
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[[Category: Chen X]]
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[[Category: Liao, X]]
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[[Category: Jin C]]
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[[Category: Marsden, I]]
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[[Category: Liao X]]
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[[Category: Dyanamic]]
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[[Category: Marsden I]]
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[[Category: Genesis]]
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[[Category: Protein-dna complex]]
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[[Category: Winged helix protein]]
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Current revision

STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX

PDB ID 2hdc

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