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1dzf

From Proteopedia

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[[Image:1dzf.jpg|left|200px]]
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{{STRUCTURE_1dzf| PDB=1dzf | SCENE= }}
{{STRUCTURE_1dzf| PDB=1dzf | SCENE= }}
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'''RPB5 FROM S.CEREVISIAE'''
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===RPB5 FROM S.CEREVISIAE===
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==Overview==
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Eukaryotic nuclei contain three different types of RNA polymerases (RNAPs), each consisting of 12-18 different subunits. The evolutionarily highly conserved RNAP subunit RPB5 is shared by all three enzymes and therefore represents a key structural/functional component of all eukaryotic RNAPs. Here we present the crystal structure of the RPB5 subunit from Saccharomyces cerevisiae. The bipartite structure includes a eukaryote-specific N-terminal domain and a C-terminal domain resembling the archaeal RNAP subunit H. RPB5 has been implicated in direct protein-protein contacts with transcription factor IIB, one of the components of the RNAP(II) basal transcriptional machinery, and gene-specific activator proteins, such as the hepatitis B virus transactivator protein X. The experimentally mapped regions of RPB5 involved in these interactions correspond to distinct and surface-exposed alpha-helical structures.
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(as it appears on PubMed at http://www.pubmed.gov), where 10841537 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10841537}}
==About this Structure==
==About this Structure==
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[[Category: Weinzierl, R O.J.]]
[[Category: Weinzierl, R O.J.]]
[[Category: Rna polymerase subunit]]
[[Category: Rna polymerase subunit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:28:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:53:09 2008''

Revision as of 20:53, 30 June 2008

Image:1dzf.png

Template:STRUCTURE 1dzf

RPB5 FROM S.CEREVISIAE

Template:ABSTRACT PUBMED 10841537

About this Structure

1DZF is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of RPB5, a universal eukaryotic RNA polymerase subunit and transcription factor interaction target., Todone F, Weinzierl RO, Brick P, Onesti S, Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6306-10. PMID:10841537

Page seeded by OCA on Mon Jun 30 23:53:09 2008

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