7m17
From Proteopedia
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==SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1)== | ==SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1)== | ||
| - | <StructureSection load='7m17' size='340' side='right'caption='[[7m17]]' scene=''> | + | <StructureSection load='7m17' size='340' side='right'caption='[[7m17]], [[Resolution|resolution]] 3.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M17 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7m17]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M17 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m17 OCA], [https://pdbe.org/7m17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m17 RCSB], [https://www.ebi.ac.uk/pdbsum/7m17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m17 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene>, <scene name='pdbligand=YNJ:7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic+acid'>YNJ</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Lrrc8a, Lrrc8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m17 OCA], [https://pdbe.org/7m17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m17 RCSB], [https://www.ebi.ac.uk/pdbsum/7m17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m17 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE]] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Brohawn | + | [[Category: Lk3 transgenic mice]] |
| - | [[Category: Gerber | + | [[Category: Brohawn, S G]] |
| - | [[Category: Kern | + | [[Category: Gerber, E E]] |
| + | [[Category: Kern, D M]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 09:01, 29 September 2021
SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1)
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