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6jpd

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Current revision (10:52, 14 June 2023) (edit) (undo)
 
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==Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR==
==Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR==
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<StructureSection load='6jpd' size='340' side='right'caption='[[6jpd]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='6jpd' size='340' side='right'caption='[[6jpd]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6jpd]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JPD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6jpd]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JPD FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ripk3, Rip3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jpd OCA], [https://pdbe.org/6jpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jpd RCSB], [https://www.ebi.ac.uk/pdbsum/6jpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jpd ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jpd OCA], [https://pdbe.org/6jpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jpd RCSB], [https://www.ebi.ac.uk/pdbsum/6jpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jpd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE]] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>
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[https://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Dong XQ]]
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[[Category: Dong, X Q]]
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[[Category: Hu H]]
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[[Category: Hu, H]]
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[[Category: Lu JX]]
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[[Category: Lu, J X]]
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[[Category: Schwieters C]]
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[[Category: Schwieters, C]]
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[[Category: Wang HY]]
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[[Category: Wang, H Y]]
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[[Category: Wang J]]
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[[Category: Wang, J]]
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[[Category: Wu XL]]
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[[Category: Wu, X L]]
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[[Category: Zhang J]]
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[[Category: Zhang, J]]
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[[Category: Amyloid]]
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[[Category: Programmed necrosis]]
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[[Category: Protein fibril]]
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Current revision

Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR

PDB ID 6jpd

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