1dzo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1dzo.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1dzo.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1dzo| PDB=1dzo | SCENE= }}
{{STRUCTURE_1dzo| PDB=1dzo | SCENE= }}
-
'''TRUNCATED PAK PILIN FROM PSEUDOMONAS AERUGINOSA'''
+
===TRUNCATED PAK PILIN FROM PSEUDOMONAS AERUGINOSA===
-
==Overview==
+
<!--
-
Fibers of pilin monomers (pili) form the dominant adhesin of Pseudomonas aeruginosa, and they play an important role in infections by this opportunistic bacterial pathogen. Blocking adhesion is therefore a target for vaccine development. The receptor-binding site is located in a C-terminal disulphide-bonded loop of each pilin monomer, but functional binding sites are displayed only at the tip of the pilus. A factor complicating vaccination is that different bacterial strains produce distinct, and sometimes highly divergent, pilin variants. It is surprising that all strains still appear to bind a common receptor, asialo-GM1. Here, we present the 1.63 A crystal structure of pilin from P. aeruginosa strain PAK. The structure shows that the proposed receptor-binding site is formed by two beta-turns that create a surface dominated by main-chain atoms. Receptor specificity could therefore be maintained, whilst allowing side-chain variation, if the main-chain conformation is conserved. The location of the binding site relative to the proposed packing of the pilus fiber raises new issues and suggests that the current fiber model may have to be reconsidered. Finally, the structure of the C-terminal disulphide-bonded loop will provide the template for the structure-based design of a consensus sequence vaccine.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10843854}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10843854 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10843854}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Type iv pilin]]
[[Category: Type iv pilin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:28:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:54:06 2008''

Revision as of 20:54, 30 June 2008

Image:1dzo.png

Template:STRUCTURE 1dzo

TRUNCATED PAK PILIN FROM PSEUDOMONAS AERUGINOSA

Template:ABSTRACT PUBMED 10843854

About this Structure

1DZO is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Crystal structure of Pseudomonas aeruginosa PAK pilin suggests a main-chain-dominated mode of receptor binding., Hazes B, Sastry PA, Hayakawa K, Read RJ, Irvin RT, J Mol Biol. 2000 Jun 16;299(4):1005-17. PMID:10843854

Page seeded by OCA on Mon Jun 30 23:54:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dzo"
Personal tools