7cn4

<table><tr><td colspan='2'>[[7cn4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bat_coronavirus_ra4991 Bat coronavirus ra4991]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CN4 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

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== Publication Abstract from PubMed ==

In recognizing the host cellular receptor and mediating fusion of virus and cell membranes, the spike (S) glycoprotein of coronaviruses is the most critical viral protein for cross-species transmission and infection. Here we determined the cryo-EM structures of the spikes from bat (RaTG13) and pangolin (PCoV_GX) coronaviruses, which are closely related to SARS-CoV-2. All three receptor-binding domains (RBDs) of these two spike trimers are in the "down" conformation, indicating they are more prone to adopt the receptor-binding inactive state. However, we found that the PCoV_GX, but not the RaTG13, spike is comparable to the SARS-CoV-2 spike in binding the human ACE2 receptor and supporting pseudovirus cell entry. We further identified critical residues in the RBD underlying different activities of the RaTG13 and PCoV_GX/SARS-CoV-2 spikes. These results collectively indicate that tight RBD-ACE2 binding and efficient RBD conformational sampling are required for the evolution of SARS-CoV-2 to gain highly efficient infection.

Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution.,Zhang S, Qiao S, Yu J, Zeng J, Shan S, Tian L, Lan J, Zhang L, Wang X Nat Commun. 2021 Mar 11;12(1):1607. doi: 10.1038/s41467-021-21767-3. PMID:33707453<ref>PMID:33707453</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 7cn4" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Bat coronavirus ra4991]]

[[Category: Qiao, S]]

[[Category: Tian, L]]

[[Category: Wang, X]]

[[Category: Yu, J]]

[[Category: Zeng, J]]

[[Category: Zhang, S]]

[[Category: Viral protein]]