1e0a

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[[Image:1e0a.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1e0a| PDB=1e0a | SCENE= }}
{{STRUCTURE_1e0a| PDB=1e0a | SCENE= }}
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'''CDC42 COMPLEXED WITH THE GTPASE BINDING DOMAIN OF P21 ACTIVATED KINASE'''
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===CDC42 COMPLEXED WITH THE GTPASE BINDING DOMAIN OF P21 ACTIVATED KINASE===
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==Overview==
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The Rho family GTPases, Cdc42, Rac and Rho, regulate signal transduction pathways via interactions with downstream effector proteins. We report here the solution structure of Cdc42 bound to the GTPase binding domain of alphaPAK, an effector of both Cdc42 and Rac. The structure is compared with those of Cdc42 bound to similar fragments of ACK and WASP, two effector proteins that bind only to Cdc42. The N-termini of all three effector fragments bind in an extended conformation to strand beta2 of Cdc42, and contact helices alpha1 and alpha5. The remaining residues bind to switches I and II of Cdc42, but in a significantly different manner. The structure, together with mutagenesis data, suggests reasons for the specificity of these interactions and provides insight into the mechanism of PAK activation.
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The line below this paragraph, {{ABSTRACT_PUBMED_10802735}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10802735 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10802735}}
==About this Structure==
==About this Structure==
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1E0A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0A OCA].
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1E0A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0A OCA].
==Reference==
==Reference==
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[[Category: Venkatesan, M.]]
[[Category: Venkatesan, M.]]
[[Category: G protein signalling ser/thr kinase]]
[[Category: G protein signalling ser/thr kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:29:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:55:23 2008''

Revision as of 20:55, 30 June 2008

Image:1e0a.png

Template:STRUCTURE 1e0a

CDC42 COMPLEXED WITH THE GTPASE BINDING DOMAIN OF P21 ACTIVATED KINASE

Template:ABSTRACT PUBMED 10802735

About this Structure

1E0A is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full experimental information is available from OCA.

Reference

Structure of Cdc42 bound to the GTPase binding domain of PAK., Morreale A, Venkatesan M, Mott HR, Owen D, Nietlispach D, Lowe PN, Laue ED, Nat Struct Biol. 2000 May;7(5):384-8. PMID:10802735

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