2i38

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Current revision (19:03, 29 May 2024) (edit) (undo)
 
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==Solution structure of the RRM of SRp20==
==Solution structure of the RRM of SRp20==
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<StructureSection load='2i38' size='340' side='right'caption='[[2i38]], [[NMR_Ensembles_of_Models | 19 NMR models]]' scene=''>
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<StructureSection load='2i38' size='340' side='right'caption='[[2i38]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2i38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I38 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2i38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I38 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2i2y|2i2y]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [https://pdbe.org/2i38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [https://www.ebi.ac.uk/pdbsum/2i38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i38 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [https://pdbe.org/2i38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [https://www.ebi.ac.uk/pdbsum/2i38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i38 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SRSF3_HUMAN SRSF3_HUMAN] Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).<ref>PMID:11336712</ref> <ref>PMID:17036044</ref> <ref>PMID:18364396</ref> <ref>PMID:26876937</ref> <ref>PMID:28984244</ref> <ref>PMID:32440474</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Allain, F H.T]]
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[[Category: Allain FHT]]
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[[Category: Hargous, Y F]]
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[[Category: Hargous YF]]
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[[Category: Alpha-beta sandwich]]
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[[Category: Beta1-alpha1-beta2-beta3-alpha2-beta4]]
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[[Category: Rna binding protein-chimera complex]]
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[[Category: Rrm]]
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Current revision

Solution structure of the RRM of SRp20

PDB ID 2i38

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