This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
User:Tori Templin/Sandbox 1
From Proteopedia
(Difference between revisions)
| Line 18: | Line 18: | ||
== Structural highlights == | == Structural highlights == | ||
[https://en.wikipedia.org/wiki/Tetramer tetramer] | [https://en.wikipedia.org/wiki/Tetramer tetramer] | ||
| - | <scene name='87/877604/Colored_dimer/2'>Active Dimer</scene> | + | <scene name='87/877604/Colored_dimer/2'>Active Dimer of ACAT</scene> |
<scene name='87/877604/Practice2/1'>protein orientation</scene> | <scene name='87/877604/Practice2/1'>protein orientation</scene> | ||
| + | <scene name='87/877604/Dimer_interface/1'>Dimer-Dimer Interface</scene> | ||
== Relevance == | == Relevance == | ||
talk about inhibitor CI-976 | talk about inhibitor CI-976 | ||
[[Image: CI-976.jpg|300 px|right|thumb|Figure 2. CI-976 Inhibitor]] | [[Image: CI-976.jpg|300 px|right|thumb|Figure 2. CI-976 Inhibitor]] | ||
| - | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
Revision as of 19:19, 30 March 2021
Acyl-Coenzyme A Cholesterol Acyltransferase
| |||||||||||
References
- ↑ Farese RV Jr. The nine lives of ACAT inhibitors. Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1684-6. doi:, 10.1161/01.ATV.0000227511.35456.90. PMID:16857957 doi:http://dx.doi.org/10.1161/01.ATV.0000227511.35456.90
- ↑ Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L. Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun. 2020 May 18;11(1):2478. doi: 10.1038/s41467-020-16288-4. PMID:32424158 doi:http://dx.doi.org/10.1038/s41467-020-16288-4
- ↑ Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020 May;581(7808):333-338. doi: 10.1038/s41586-020-2290-0. Epub 2020 May, 13. PMID:32433614 doi:http://dx.doi.org/10.1038/s41586-020-2290-0
Student Contributors
- Tori Templin
- Haylie Moehlenkamp
- Megan Fleshman
