1e0l

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[[Image:1e0l.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1e0l| PDB=1e0l | SCENE= }}
{{STRUCTURE_1e0l| PDB=1e0l | SCENE= }}
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'''FBP28WW DOMAIN FROM MUS MUSCULUS'''
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===FBP28WW DOMAIN FROM MUS MUSCULUS===
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==Overview==
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Two new NMR structures of WW domains, the mouse formin binding protein and a putative 84.5 kDa protein from Saccharomyces cerevisiae, show that this domain, only 35 amino acids in length, defines the smallest monomeric triple-stranded antiparallel beta-sheet protein domain that is stable in the absence of disulfide bonds, tightly bound ions or ligands. The structural roles of conserved residues have been studied using site-directed mutagenesis of both wild type domains. Crucial interactions responsible for the stability of the WW structure have been identified. Based on a network of highly conserved long range interactions across the beta-sheet structure that supports the WW fold and on a systematic analysis of conserved residues in the WW family, we have designed a folded prototype WW sequence.
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The line below this paragraph, {{ABSTRACT_PUBMED_10802733}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10802733 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10802733}}
==About this Structure==
==About this Structure==
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1E0L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0L OCA].
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1E0L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0L OCA].
==Reference==
==Reference==
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[[Category: Signal transduction]]
[[Category: Signal transduction]]
[[Category: Ww domain]]
[[Category: Ww domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:30:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:56:26 2008''

Revision as of 20:56, 30 June 2008

Image:1e0l.png

Template:STRUCTURE 1e0l

FBP28WW DOMAIN FROM MUS MUSCULUS

Template:ABSTRACT PUBMED 10802733

About this Structure

1E0L is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Structural analysis of WW domains and design of a WW prototype., Macias MJ, Gervais V, Civera C, Oschkinat H, Nat Struct Biol. 2000 May;7(5):375-9. PMID:10802733

Page seeded by OCA on Mon Jun 30 23:56:26 2008

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