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6wuv

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Current revision (14:36, 18 October 2023) (edit) (undo)
 
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<StructureSection load='6wuv' size='340' side='right'caption='[[6wuv]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
<StructureSection load='6wuv' size='340' side='right'caption='[[6wuv]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6wuv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WUV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6wuv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WUV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ELT:ethoxy-~{N},~{N}-dimethyl-phosphonamidic+acid'>ELT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACHE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ELT:ethoxy-~{N},~{N}-dimethyl-phosphonamidic+acid'>ELT</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wuv OCA], [https://pdbe.org/6wuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wuv RCSB], [https://www.ebi.ac.uk/pdbsum/6wuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wuv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wuv OCA], [https://pdbe.org/6wuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wuv RCSB], [https://www.ebi.ac.uk/pdbsum/6wuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wuv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>
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[https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acetylcholinesterase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bester, S M]]
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[[Category: Bester SM]]
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[[Category: Height, J J]]
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[[Category: Height JJ]]
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[[Category: McGuire, J R]]
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[[Category: McGuire JR]]
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[[Category: Pegan, S D]]
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[[Category: Pegan SD]]
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[[Category: Ga]]
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[[Category: Hydrolase]]
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[[Category: Nerve agent]]
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[[Category: Tabun]]
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Current revision

Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GA

PDB ID 6wuv

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