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6wsi

From Proteopedia

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Current revision (14:35, 18 October 2023) (edit) (undo)
 
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<StructureSection load='6wsi' size='340' side='right'caption='[[6wsi]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='6wsi' size='340' side='right'caption='[[6wsi]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6wsi]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WSI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6wsi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WSI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLV:GLYOXYLIC+ACID'>GLV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=U9S:(2R,3S)-oxirane-2,3-dicarboxylic+acid'>U9S</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.749&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Isocitrate_lyase Isocitrate lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.1 4.1.3.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLV:GLYOXYLIC+ACID'>GLV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=U9S:(2R,3S)-oxirane-2,3-dicarboxylic+acid'>U9S</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wsi OCA], [https://pdbe.org/6wsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wsi RCSB], [https://www.ebi.ac.uk/pdbsum/6wsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wsi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wsi OCA], [https://pdbe.org/6wsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wsi RCSB], [https://www.ebi.ac.uk/pdbsum/6wsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wsi ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACEA_MYCTU ACEA_MYCTU] Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Isocitrate lyase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Krieger, I V]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Meek, T D]]
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[[Category: Krieger IV]]
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[[Category: Mellott, D]]
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[[Category: Meek TD]]
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[[Category: Sacchettini, J C]]
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[[Category: Mellott D]]
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[[Category: Structural genomic]]
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[[Category: Sacchettini JC]]
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[[Category: Covalent inhibitor]]
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[[Category: Enzyme]]
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[[Category: Lyase]]
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[[Category: Psi-biology]]
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[[Category: Substrate analog]]
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[[Category: Tbsgc]]
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Current revision

Intact cis-2,3-epoxysuccinic acid bound to Isocitrate Lyase-1 from Mycobacterium tuberculosis

PDB ID 6wsi

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