7bb3

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==Structure of S. pombe YG-box oligomer==
==Structure of S. pombe YG-box oligomer==
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<StructureSection load='7bb3' size='340' side='right'caption='[[7bb3]]' scene=''>
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<StructureSection load='7bb3' size='340' side='right'caption='[[7bb3]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BB3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7bb3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BB3 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bb3 OCA], [https://pdbe.org/7bb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bb3 RCSB], [https://www.ebi.ac.uk/pdbsum/7bb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bb3 ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">smn1, yab8, SPAC2G11.08c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bb3 OCA], [https://pdbe.org/7bb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bb3 RCSB], [https://www.ebi.ac.uk/pdbsum/7bb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bb3 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/SMN1_SCHPO SMN1_SCHPO]] Has been implicated indirectly in general cellular RNA processing. Plays a crucial role in the generation of the pre-mRNA splicing machinery and in mRNA biogenesis by interacting with spliceosomal snRNPs.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The macromolecular SMN complex facilitates the formation of Sm-class ribonucleoproteins involved in mRNA processing (UsnRNPs). While biochemical studies have revealed key activities of the SMN complex, its structural investigation is lagging behind. Here we report on the identification and structural determination of the SMN complex from the lower eukaryote Schizosaccharomyces pombe, consisting of SMN, Gemin2, 6, 7, 8 and Sm proteins. The core of the SMN complex is formed by several copies of SMN tethered through its C-terminal alpha-helices arranged with alternating polarity. This creates a central platform onto which Gemin8 binds and recruits Gemins 6 and 7. The N-terminal parts of the SMN molecules extrude via flexible linkers from the core and enable binding of Gemin2 and Sm proteins. Our data identify the SMN complex as a multivalent hub where Sm proteins are collected in its periphery to allow their joining with UsnRNA.
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Identification and structural analysis of the Schizosaccharomyces pombe SMN complex.,Veepaschit J, Viswanathan A, Bordonne R, Grimm C, Fischer U Nucleic Acids Res. 2021 Jul 21;49(13):7207-7223. doi: 10.1093/nar/gkab158. PMID:33754639<ref>PMID:33754639</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7bb3" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fission yeast]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Fischer U]]
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[[Category: Fischer, U]]
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[[Category: Grimm C]]
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[[Category: Grimm, C]]
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[[Category: Veepaschit J]]
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[[Category: Veepaschit, J]]
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[[Category: Biogenesis]]
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[[Category: Oligomerization]]
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[[Category: Smn]]
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[[Category: Splicing]]
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[[Category: Usnrnp]]

Revision as of 10:46, 28 July 2021

Structure of S. pombe YG-box oligomer

PDB ID 7bb3

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