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7l1a

From Proteopedia

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Current revision (15:36, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7l1a' size='340' side='right'caption='[[7l1a]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
<StructureSection load='7l1a' size='340' side='right'caption='[[7l1a]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7l1a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L1A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7l1a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L1A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XE1:N,N-(dihydroxy-lambda~5~-phosphanediyl)bis(phosphoramidic+acid)'>XE1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAT2A, AMS2, MATA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XE1:N,N-(dihydroxy-lambda~5~-phosphanediyl)bis(phosphoramidic+acid)'>XE1</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l1a OCA], [https://pdbe.org/7l1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l1a RCSB], [https://www.ebi.ac.uk/pdbsum/7l1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l1a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l1a OCA], [https://pdbe.org/7l1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l1a RCSB], [https://www.ebi.ac.uk/pdbsum/7l1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l1a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN]] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
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[https://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7l1a" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7l1a" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[S-adenosylmethionine synthetase 3D structures|S-adenosylmethionine synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Methionine adenosyltransferase]]
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[[Category: Fedorov E]]
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[[Category: Fedorov, E]]
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[[Category: Ghosh A]]
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[[Category: Ghosh, A]]
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[[Category: Niland CN]]
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[[Category: Niland, C N]]
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[[Category: Schramm VL]]
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[[Category: Schramm, V L]]
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[[Category: Enzyme mechanism]]
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[[Category: Inhibitor]]
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[[Category: S-adenosylmethionine]]
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[[Category: Sam synthetase]]
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[[Category: Transferase-inhibitor complex]]
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Current revision

Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor, di-imido triphosphate (PNPNP)

PDB ID 7l1a

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