1gnd

<table><tr><td colspan='2'>[[1gnd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GND FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnd OCA], [https://pdbe.org/1gnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gnd RCSB], [https://www.ebi.ac.uk/pdbsum/1gnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnd ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/GDIA_BOVIN GDIA_BOVIN]] Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

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== Publication Abstract from PubMed ==

The crystal structure of the bovine alpha-isoform of Rab GDP-dissociation inhibitor (GDI), which functions in vesicle-membrane transport to recycle and regulate Rab GTPases, has been determined to a resolution of 1.81 A. GDI is constructed of two main structural units, a large complex multisheet domain I and a smaller alpha-helical domain II. The structural organization of domain I is surprisingly closely related to FAD-containing monooxygenases and oxidases. Sequence-conserved regions common to GDI and the choroideraemia gene product, which delivers Rab to catalytic subunits of Rab geranylgeranyltransferase II, are clustered on one face of the molecule. The two most sequence-conserved regions, which form a compact structure at the apex of GDI, are shown by site-directed mutagenesis to play a critical role in the binding of Rab proteins.

Structure and mutational analysis of Rab GDP-dissociation inhibitor.,Schalk I, Zeng K, Wu SK, Stura EA, Matteson J, Huang M, Tandon A, Wilson IA, Balch WE Nature. 1996 May 2;381(6577):42-8. PMID:8609986<ref>PMID:8609986</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Balch, W E]]

[[Category: Huang, M]]

[[Category: Metteson, J]]

[[Category: Schalk, I]]

[[Category: Stura, E A]]

[[Category: Tandon, A]]

[[Category: Wilson, I A]]

[[Category: Wu, S K]]

[[Category: Zeng, K]]

[[Category: Gtpase activation]]